Cytotec (Misoprostol) is a prostaglandin analog used to prevent stomach ulcers in patients taking NSAIDs (aspirin, ibuprofen, etc.). It protects the stomach lining by replacing natural prostaglandins that NSAIDs deplete. Effects begin within 30 minutes and last up to 3 hours.
Dosage & Administration
- Standard dose: 200 mcg (0.2 mg) 3-4 times daily with meals (including before bedtime).
- If poorly tolerated: Reduce to 100 mcg (0.1 mg) per dose.
- Take with food to minimize diarrhea risk.
- Avoid magnesium antacids (may worsen diarrhea).
Precautions
- High risk of diarrhea—use cautiously in patients with:
- Inflammatory bowel disease (IBD)
- Dehydration susceptibility
- Not for:
- Pregnant women (risk of miscarriage, birth defects)
- Breastfeeding mothers
- Patients under 18 years old
- Severe kidney impairment
Side Effects
Common:
- Diarrhea
- Abdominal pain
- Nausea, vomiting
- Flatulence
- Menstrual cramps
Rare but serious:
- Severe allergic reactions (rash, swelling, breathing difficulty)
- Drowsiness, tremors
- Irregular heartbeat, low blood pressure
Overdose & Missed Dose
- Overdose symptoms:
- Severe diarrhea, stomach pain
- Drowsiness, tremors, seizures
- Irregular heartbeat, difficulty breathing
- Seek emergency help immediately.
- Missed dose:
- Take as soon as remembered.
- Skip if close to next dose—never double dose.
Storage
- Keep at room temperature (15-30°C / 59-86°F).
- Store in a tight, dry container, away from light and moisture.
- Keep out of reach of children and pets.
Note:
- Do not use during pregnancy—can cause abortion or birth defects.
- No major drug interactions reported, but consult a doctor before combining with other medications.
- If severe diarrhea occurs, reduce dose or discontinue use.
Always follow your doctor's instructions for safe and effective treatment.